AKAO 2017 Annual Report

2 ACHAOGEN, INC. ANNUAL REPORT ON FORM 10-K TABLE OF CONTENTS Page Part I. Item 1. Business ............................................................................................................................................. 3 Item 1A. Risk Factors ....................................................................................................................................... 38 Item 1B. Unresolved Staff Comments .............................................................................................................. 80 Item 2. Properties ........................................................................................................................................... 80 Item 3. Legal Proceedings.............................................................................................................................. 80 Item 4. Mine Safety Disclosures .................................................................................................................... 80 Part II. Item 5. Market for Registrant's Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities ...................................................................................................................... 81 Item 6. Selected Financial Data...................................................................................................................... 83 Item 7. Management's Discussion and Analysis of Financial Condition and Results of Operations ............ 85 Item 7A. Quantitative and Qualitative Disclosures About Market Risk........................................................... 101 Item 8. Financial Statements and Supplementary Data.................................................................................. 102 Item 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure............ 136 Item 9A. Controls and Procedures .................................................................................................................... 136 Item 9B. Other Information .............................................................................................................................. 139 Part III. Item 10. Directors, Executive Officers and Corporate Governance ................................................................ 141 Item 11. Executive Compensation ................................................................................................................... 141 Item 12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters ..................................................................................................................................... 141 Item 13. Certain Relationships and Related Transactions, and Director Independence .................................. 141 Item 14. Principal Accounting Fees and Services............................................................................................ 141 Part IV. Item 15. Exhibits, Financial Statement Schedules ........................................................................................... 142 Item 16. Form 10-K Summary ......................................................................................................................... 147 Signatures........................................................................................................................................... 148