AKAO 2017 Annual Report

146 Incorporated by Reference from Provided Herewith Exhibit Number Description of Document Registrant's Form File No. Date Filed with the SEC Exhibit Number 10.25† Letter Agreement by and between the Bill & Melinda Gates Foundation and the Company, dated May 4, 2017. 10-Q 001-36323 8/8/2017 10.1 10.26† Validation and Manufacturing Agreement, dated March 5, 2017, by and between the Company and Hovione Limited. 10-Q 001-36323 5/8/2017 10.3 10.27(A)† Collaborative Development and Commercialization Agreement, dated April 26, 2016, by and between the Company and Microgenics Corporation. 10-Q 001-36323 5/8/2017 10.5 10.27(B)* * Amendment #1, dated November 29 2017, to the Collaborative Development and Commercialization Agreement, dated April 26, 2016, by and between the Company and Microgenics Corporation. X 10.28 Loan and Security Agreement, dated February 26, 2018, by and between the Company and Silicon Valley Bank X 12.1 Statement Regarding the Computation of Ratio of Earnings to Fixed Charges. X 23.1 Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm. X 23.2 Consent of Latham & Watkins LLP (included in Exhibit 5.1). X 24.1 Power of Attorney (included on signature page hereto). X 31.1 Certification of Principal Executive Officer Required Under Rule 13a-14(a) and 15d-14(a) of the Securities Exchange Act of 1934, as amended. X 31.2 Certification of Principal Financial Officer Required Under Rule 13a-14(a) and 15d-14(a) of the Securities Exchange Act of 1934, as amended. X 32.1* Certification of Principal Executive Officer and Principal Financial Officer Required Under Rule 13a-14(b) of the Securities Exchange Act of 1934, as amended, and 18 U.S.C. §1350. X 101.INS XBRL Instance Document. X 101.SCH XBRL Taxonomy Extension Schema Document. X 101.CAL XBRL Taxonomy Extension Calculation Linkbase Document. X