NH 2021 Annual Report

1. A rapid evolution from traditional fee-for-service to patient-centered and patient-empowered, value-based models driven by quantifiable measures of outcomes relative to cost. Unsustainable escalating healthcare costs, which we believe are due to broken fee-for-service models, are driving many stakeholders and governments toward alternative delivery models. Despite significant investments in electronic health records ("EHRs") and other technologies designed to enable the transition to more value-based care, we believe that, in a fee-for-service model, the economic incentives generally discourage coordination among healthcare stakeholders and encourage volume-driven (rather than outcomes-driven) decision-making. This model results in healthcare and financial data that remains largely segregated into “walled gardens.” Thus, patient data often remains static and cannot be easily shared or interpreted due to siloed legacy proprietary platforms that lack interoperability. 2. The rise of evidence-based care to ensure patients receive the most effective care at the most appropriate cost. As drug prices soar and the overall expense of cancer and autoimmune care increases, unnecessary or inappropriate therapy has never been more costly. We believe leveraging the ever-evolving body of evidence-based standards of care can drive better and more efficient outcomes for members. Evidence-based care eliminates unwarranted variability by applying nationally accepted treatment standards at the moment of clinical prescribing, ensuring that compliance takes place at the front-end of care as opposed to the back-end review after treatment has begun. Evidence-based treatment that offers the best-expected outcome at a better cost than a competing therapy also supports the transformative shift to value-based care that benefits all parties. 3. Growing focus on health equity and the personalized care path members and patients need. Recent events, including the disproportionate impact of COVID-19 on communities of color, have raised awareness of the healthcare industry’s need to move towards a care delivery system that views members holistically. For example, we understand a cancer patient’s journey may be impacted by factors outside of the care system, like socioeconomic status – the neighborhoods and environments in which they work and live, and barriers such as internet, transportation, and healthy food availability. Access to information and social trust of patients differ, and those differences are too often put aside in the current standard of care thinking. We believe these shifts, and the associated challenges, require advanced technology systems and data expertise that our customers cannot quickly and easily develop on their own. Our unique portfolio of technology solutions allows us to collect, interpret and deliver data insights that help our customers improve their businesses, provide decision support with a comprehensive knowledge base of evidence-based treatment options, and help both payers and providers effectively transition to value-based care. Given the magnitude of these shifts and the difficulty involved in addressing the associated challenges, we believe our solution platforms serve to position NantHealth at the forefront of multiple market opportunities. We have invested significant capital, software development, data and healthcare expertise over a decade to develop, acquire and integrate the components that we believe address many of the challenges faced by stakeholders across the continuum of care. Our Strategy Our goal is to become the leading provider of solutions that enable enterprises to leverage actionable data insights. In the healthcare space, we seek to facilitate payer and provider collaboration, and to leverage clinical data and knowledge towards delivering improved patient outcomes and more effective treatment decisions for critical illnesses. To accomplish this goal, we plan to deploy NantHealth solutions designed to address and accelerate the transformational shifts occurring in healthcare (empowering the extraction of value from the growing abundance of data and supporting the evolution from traditional fee-forservice to value-based models), while also expanding our network monitoring solution capabilities to support the underlying infrastructure necessary to enable transformational shifts in healthcare and other industries. The key elements of our strategy include: • Leveraging NantHealth's key capabilities delivered through a comprehensive suite of solutions to unlock value from data. NantHealth’s solution capabilities include: • SaaS-based platforms: our enterprise-grade platforms are designed for automation, security, ease-of-use and scalability; • Evidence-based support: our robust database and analysis of FDA-approved treatment options improves decision support while reducing waste; • Real-world enabled insights: our solutions can provide real-world evidence that demonstrates effectiveness, safety and value; • Network performance: our OpenNMS services provide a highly scalable, reliable, and extensible platform for network monitoring; and • Interoperability: we connect and normalize data for real-time collaboration and information exchange. - 7 -

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